Related Products of 111-45-5, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 111-45-5 as follows.
The compound of formula (J2) (20.0 g), 2-allyloxy ethanol (300 g), a 10 weight % ethanol solution of potassium acetate (0.5 g) and an isopropyl alcohol solution of chloroplatinic acid (0.2 weight % as platinum, 0.5 g) were introduced into a 300 mL eggplant type flask equipped with a reflux condenser and magnetic rotor, and a reaction was carried out for 3.5 hours in an oil bath of 90C as the mixture was being stirred. The low boiling point components were removed with a rotary vacuum evaporator. Purification was performed by silica gel column chromatography (developing solvent, ethyl acetate/hexane) and a pale yellow transparent liquid was obtained. The proton nuclear magnetic resonance spectrum of this liquid was analyzed. As a result, peaks were detected in the vicinity of 0.1 ppm (18H), in the vicinity of 0.5 ppm (8H), in the vicinity of 1.6 ppm (8H), in the vicinity of 1.9 ppm (3H), in the vicinity of 2.5 ppm (3H), in the vicinity of 3.4 ppm (6H), in the vicinity of 3.5 ppm (6H), in the vicinity of 3.7 ppm (6H), in the vicinity of 4.1 ppm (2H), in the vicinity of 5.5 ppm (1H) and in the vicinity of 6.1 ppm (1H). From these findings, it was confirmed that this was the compound represented by formula (M4).
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,111-45-5, its application will become more common.
Reference:
Patent; Johson & Johnson Vision Care Inc.; EP1424339; (2004); A1;,
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