Reference of 445-26-1, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 445-26-1, name is 1-(2-Fluorophenyl)ethanol. A new synthetic method of this compound is introduced below.
h. 1-(2-Fluorophenyl)ethyl chloride was prepared as follows: Thionyl chloride (100 ml.) was added to a solution of 1-(2-fluorophenyl)ethanol [described by McCall, J.A.C.S. 74, 4809 (1952)] (105 g.) in dry chloroform (200 ml.). After the vigorous initial reaction had subsided, the solution was heated at reflux on a steam bath for 30 minutes. The excess of thionyl chloride was removed by repeated co-distillation with dry toluene and the residue was diluted with diethyl ether, washed with water (2 * 100 ml.), dried over sodium sulphate, filtered and evaporated to a yellow liquid, which was distilled to give 1-(2-fluorophenyl)ethyl chloride (73.2 g.), b.p. 70-75 C./20 mm.Hg, as a pale yellow oil. By proceeding in a similar manner but replacing 1-(2-fluorophenyl)ethanol by the appropriate phenyl ethanols there were prepared:
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,445-26-1, its application will become more common.
Reference:
Patent; May & Baker Limited; US4067723; (1978); A;,
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