Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 4442-79-9, name is 2-Cyclohexylethanol. A new synthetic method of this compound is introduced below., category: alcohols-buliding-blocks
150 mg (1.17 mmol, 1 eq) of 2-cyclohexylethanol were diluted in 4 mL of DCM, 214 muL (1.52 mmol, 1.3 eq) of triethylamine were added. The mixture was cooled to 0C and 100 muL (1.29 mmol, 1.1 eq) of mesyl chloride were added. The mixture was stirred for 15 min at 00C then water was added. The aqueous phase was extracted with dichloromethane. The organic phase was washed with water, brine, dried over MgSO4, filtered and concentrated in vacuo. The crude product (241 mg) was used directly for synthesis of 2. TLC : Rf : 0.48 (eluant : Heptane/EtOAc : 1/1).
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Reference:
Patent; AMGEN INC.; WO2009/9122; (2009); A2;,
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