In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 27489-62-9, name is trans-4-Aminocyclohexanol, the common compound, a new synthetic route is introduced below. Product Details of 27489-62-9
A mixture of Methyl 2-bromo-1 -methyl-1 H-benzimidazoIe-5-carboxylate (37.0 g, 0.137 mol), frans-4-aminocyclohexanol (38.0 g, 0.33 mol), cesium fluoride CsF (29.24 g, 0.29 mol), and DMSO (350 mL) was stirred at 110 C for 6 h and kept overnight at room temperature (TLC control, silica gel, chloroform/ethanol 20:1 ). The reaction mixture was poured into cold water (1.5 L). The precipitate was separated by filtration and recrystallized from acetonitrile (900 mL) to give the title compound in 84% (35.0 g) yield.
The synthetic route of 27489-62-9 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; PFIZER PRODUCTS INC.; WO2007/69053; (2007); A1;,
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