Related Products of 29683-23-6, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 29683-23-6, name is Tetrahydro-2H-thiopyran-4-ol, molecular formula is C5H10OS, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
Phosphorus tribromide (3.9 g, 14 mmol) was added dropwise in 30 min to a solution of alcohol 5 (3.73 g, 32 mmol) in CH2Cl2 (50 mL) at ambient temperature. Upon completion of the addition, the reaction mixture was slowly heated to the boiling point and stirred overnight. After cooling to room temperature the mixture was quenched with water and extracted with diethyl ether (2 × 100 mL). The organic phase was washed with a saturated solution of NaHCO3, dried over anhydrous MgSO4 and evaporated to yield 3.37 g (19 mmol, 59%) of a yellow oil. deltaH (CDCl3) 4.32 (m, 1H, CHBr), 2.90 (m, 2H, SCH2), 2.55 (m, 2H, SCH2), 2.38 (m, 2H, SCH2CH2), 2.23 (m, 2H, SCH2CH2). deltaC (CDCl3) 45.3 (CBr), 36.9 (SCC), 26.9 (SC).
According to the analysis of related databases, 29683-23-6, the application of this compound in the production field has become more and more popular.
Reference:
Article; Van Walree, Cornelis A.; Lutz, Martin; Spek, Anthony L.; Jenneskens, Leonardus W.; Havenith, Remco W.A.; Journal of Molecular Structure; vol. 1036; (2013); p. 115 – 120;,
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