Related Products of 2240-88-2, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 2240-88-2 as follows.
b) Methyl 4-(benzyloxy)-3-(3,3,3-trifluoropropoxy)benzoateDiisopropyl azodicarboxylate (0.372 mL, 1.89 mmol) and triphenylphosphine (0.489 g, 1.86 mmol) were added to a solution of methyl 4-(benzyloxy)-3-hydroxybenzoate (0.355 g, 1.37 mmol) in tetrahydrofuran (20 mL) and the resulting reaction mixture was stirred for 55 min at room temperature. 3,3,3-Trifluoro-l-propanol (0.121 mL, 1.37 mmol) was added and the reaction mixture was stirred over night. The solvent was evaporated. Purification by column chromatography, using heptane/ethyl acetate (6:1) as the eluent, gave 0.162 g (33percent yield) of the title compound. GC MS (EI) m/z 354 [M]+*.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,2240-88-2, its application will become more common.
Reference:
Patent; ASTRAZENECA AB; BYLUND, Johan; EK, Maria, E; HOLENZ, Joerg; KERS, Annika; OeHBERG, Liselotte; WO2010/132016; (2010); A1;,
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