Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 3513-81-3, name is 2-Methylenepropane-1,3-diol. A new synthetic method of this compound is introduced below., Formula: C4H8O2
Preparation 3 3-Octadecylaminocarbonyloxy-2-methylenepropan-1-ol Octadecyl isocyanate (59.1 g) and 2-methylene-propane-1,3-diol (17.7 g) were dissolved and stirred in pyridine (100 ml) for 24 hours at 22°C. Water (200 ml) was added, and the mixture was extracted with chloroform (3 * 200 ml). The chloroform extracts were washed with water, dried over anhydrous magnesium sulfate, filtered and evaporated to dryness in vacuo . The mixture was purified through a column of silica gel 60 (70-230 mesh, 100 g) eluding with chloroform/ether 1: 1. Further purification was achieved by chromatography on a Waters PrepLC.(R)./System 500A using a PrepPAK.(R).-500/SILICA cartridge with chloroform/ether/pentane 1: 1: 3 as eluent. The product was recrystallized from acetone. Mp. 71-73°C. Elemental analysis: calculated C 71.99percent, H 11.82percent, N 3.65percent, found C 71.93percent, H 11.93percent, N 3.64percent.
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Reference:
Patent; LEO PHARMACEUTICAL PRODUCTS LTD. A/S, (LOVENS KEMISKE FABRIK PRODUKTIONSAKTIESELSKAB); EP247201; (1991); B1;,
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