The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 623-69-8, name is 1,3-Dimethoxypropan-2-ol. This compound has unique chemical properties. The synthetic route is as follows. HPLC of Formula: C5H12O3
To a solution of 3-bromophenol (6g, 34.7mmol) and 1,3-dimethoxypropan-2-ol (5.OOg,41.6mmol) in THE (l5OmL) was added triphenylphosphine (13.64g, 52.Ommol) and the reaction mixture cooled to 0C followed by dropwise addition of DIAD (6.74mL, 34.7mmol). The reaction was allowed to warm to room temperature, then stirred for 12h. The reaction mixture was concentratedvacua. The obtained residue was dissolved in EtOAc (SOmL), washed with water (SOmL) and brine(SOmL), dried over Na24, concentrated in vacua and subjected to silica column chromatography(SOg column), eluting with 20% EtOAc in petroleum ether. The relevant fractions were combined andconcentrated in vacua affording the title compound (4.Og, 42%) as a yellow liquid: MS ES+ve m/z275, 277 (M–H).
With the rapid development of chemical substances, we look forward to future research findings about 623-69-8.
Reference:
Patent; GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED; ANDERSON, Niall Andrew; CAMPBELL-CRAWFORD, Matthew Howard James; HANCOCK, Ashley Paul; LEMMA, Seble; PRITCHARD, John Martin; PROCOPIOU, Panayiotis Alexandrou; REDMOND, Joanna Mary; SOLLIS, Steven Leslie; (77 pag.)WO2017/162572; (2017); A1;,
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