Adding a certain compound to certain chemical reactions, such as: 27129-87-9, (3,5-Dimethylphenyl)methanol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, COA of Formula: C9H12O, blongs to alcohols-buliding-blocks compound. COA of Formula: C9H12O
Step 1 1-(2-Aminoethyl)-3-(3,5-dimethylbenzyl)-2-imidazolidinylidenepropanedinitrile (Compound (IXa)): 1-(2-Aminoethyl)-2-imidazolidinylidenepropanedinitrile (9.7 g) obtained by a known process (JP92-279581), 5.0 g of 3,5-dimethylbenzyl alcohol, 12 g of triphenylphosphine, and 10 g of di-tert-butyl azodicarboxylate were allowed to react in 500 ml of tetrahydrofuran as described in Example 23 to give 3.6 g (34%) of Compound (IXa) as a pale yellow oily substance. 1H NMR (270 MHz, CDCl3) delta: 6.89 (1H, s), 6.81 (2H, s), 4.62 (2H, s), 3.62-3.55 (4H, m), 3.42-3.34 (2H, m), 2.98 (2H, t), 2.25 (6H, s). The signal which corresponds to primary amine was not observed.
At the same time, in my other blogs, there are other synthetic methods of this type of compound,27129-87-9, (3,5-Dimethylphenyl)methanol, and friends who are interested can also refer to it.
Reference:
Patent; Millennium Pharmaceuticals, Inc.; Kyowa Hakko Kogyo Co., Ltd.; US6469002; (2002); B1;,
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Alcohols – Chemistry LibreTexts