623-50-7, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 623-50-7, name is Ethyl 2-hydroxyacetate, molecular formula is C4H8O3, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
ethyl glycolate (10g, 96.1mmol) and a imidazole (13g, 0.19mol) was dissolved in dichloromethane (100 mL)placed in three round bottom flask, was added at 0C tert-butyldimethylsilyl chloride (15.8g, 0.1mol), the mixture was stirred for 8hours at room temperature, washed with water (100mL * 3), dried over sodium sulfate and concentrated to give the titlecompound as a yellow oil (18g, 85.8%).
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 623-50-7, Ethyl 2-hydroxyacetate, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; MEDSHINEDISCOVERY INC.; CHENXIN PHARMACEUTICAL LTD; Zheng, Huiping; Wu, Chengde; Yu, Tao; Huang, Lei; Hao, Dongling; Gao, Bo; Sun, Jikui; Shi, Nengyang; Chen, Shuhui; (151 pag.)TW2016/2107; (2016); A;,
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