As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 33036-62-3, name is 4-Bromo-1-butanol, molecular formula is C4H9BrO, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. name: 4-Bromo-1-butanol
2-(4-Bromobutoxy)-tetrahydro-2H-pyran (2): 3,4-Dihydro-2H-pyran (8.5 mL, 90.96 mmol) was added dropwise to the dichloromethane (20 mL) solution of 1 (10.7 g, 69.93 mmol) and p-toluenesulfonic acid monohydrate (26.5 mg, 0.1372 mmol). The mixture was stirred at room temperature over night. After removing the solvent, the residue was purified by flash chromatography on silica gel with 5:1 hexanes/ethyl acetate as the eluent to yield product 2 as a colorless oil (15.3 g, 92 %). 1H NMR (400 MHz, CDCI3): delta 1.48-1.62 (m, 4H), 1.68-1.85 (m, 4H), 1.94-2.02 (m, 2H), 3.40-3.53 (m, 4H), 3.74-3.88 (m, 2H), 4.57-4.59 (m, 1 H).
With the rapid development of chemical substances, we look forward to future research findings about 33036-62-3.
Reference:
Patent; DIETRICH, Evelyne; REDDY, Ranga; TANAKA, Kelly; KANG, Ting; LAFONTAINE, Yanick; RAFAI FAR, Adel; TARGANTA THERAPEUTICS CORP.; WO2010/19511; (2010); A2;,
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