Reference of 124-68-5, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 124-68-5, name is 2-Amino-2-methyl-1-propanol, molecular formula is C4H11NO, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
2-Amino-2-methyl-1-propanol (9.5 mL, 0.1 mol) and triethylamine (14 mL, 0.1 mol) were dissolved in 200 mL chloroform. The solution was cooled to 0 C using an ice bath, and added a solution of acryloyl chloride (8.0 mL, 0.1 mol) in 50 mL chloroform. The reaction mixture was then stirred for 4 h while keeping the temperature at 0 C. Triethylamine hydrochloride was precipitated from the solution, and removed by filtration. The filtrate was concentrated and purified by column chromatography using ethyl acetate/hexane (7/3, v/v) as the eluent. The HTBAM monomer was obtained as a white powder and the yield was 66.0%. 1H NMR (CDCl3, delta, ppm): 1.34 (s, 6H, C(CH3)2CH2OH), 3.62 (d, 2H, C(CH3)2CH2OH), 5.67, 6.10 (dd, dd, 2H, CH2=CH), 6.27 (dd, 1H, CH2=CH). 13C NMR (CDCl3, delta, ppm): 24.11 (C(CH3)2CH2OH), 55.84 (C(CH3)2CH2OH), 70.19 (C(CH3)2CH2OH), 126.48 (CH2=CH), 130.65 (CH2=CH), 165.93 (C=O). HR-MS (ESI): calcd for C7H13NO2 [M+H]+: 144.10191, found: 144.10186.
According to the analysis of related databases, 124-68-5, the application of this compound in the production field has become more and more popular.
Reference:
Article; Cui, Qianling; Wang, Yajie; Wu, Feipeng; Wang, Erjian; Polymer; vol. 54; 17; (2013); p. 4521 – 4527;,
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