Synthetic Route of 101597-25-5, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 101597-25-5 as follows.
Preparation of 2-(2-(2-(2-(4-(hydroxybis(4-methoxyphenyl)methyl)-1H-1,2,3-triazol-1-yl)ethoxy)ethoxy)ethoxy)ethanol (5d) The following are added to 100 mL of DCM/H2O mixture (1/1): 3 (1.988 g; 9.07 mmol; 1 eq.), 4d prepared according to Gabbutt, C. D.; Heron, B. M.; Instone, A. C.; Thomas, D. A. Partington, S. M.; Hursthouse, M. B.; Gelbrich, T. Eur. J. Org. Chem. 2003, 7, 1220; (2.379 g; 9.07 mmol; 1 eq.) and CuBr (0.260 g; 1.814 mmol; 0.2 eq.). The solution is stirred vigorously for 20 h and extracted with DCM and washed with a saturated solution of NH4Cl. The organic phase is dried (MgSO4), filtered and concentrated under vacuum. The crude product is purified (flash chromatography, silica gel, eluent DCM/MeOH) to give 5d in the form of an oil (3.463 g; 7.19 mmol; 79%). Rf (SiO2, DCM/MeOH (95/5)): 0.15,
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,101597-25-5, its application will become more common.
Reference:
Patent; INSERM (Institut National de la Sante et de la Recherche Medicale); Bertrand, Philippe; Delatouche, Regis; Heroguez, Valerie; Collette, Floraine; Gregoire, Marc; Blanquart, Christophe; Gueugnon, Fabien; US2014/219925; (2014); A1;,
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