Synthetic Route of 627-18-9, Adding some certain compound to certain chemical reactions, such as: 627-18-9, name is 3-Bromopropan-1-ol,molecular formula is C3H7BrO, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 627-18-9.
To a flask, appropriate halide (1b5 and 1b6,0.70 g) was dissolved in 15mL of acetone and then NaN3 (3-5 eq)(plus 0.1 eq of KI, when the halide was 3-Bromo-1-propanol) and5mL of H2O was added. The mixture was stirred bath at 50 C for12 h. After the reaction, the solvent was removed by rotary evaporation,and 15 mL of water was added. The solution was thenextracted by ethyl acetate for three times. The organic phase wascombined, dried and concentrated to yield the crude product whichwas used for the next step without further purification. Thismethod was applied in the preparation of 2b5 and 2b6.
According to the analysis of related databases, 627-18-9, the application of this compound in the production field has become more and more popular.
Reference:
Article; Tian, Ye; Liu, Zhaoqiang; Liu, Jinghan; Huang, Boshi; Kang, Dongwei; Zhang, Heng; De Clercq, Erik; Daelemans, Dirk; Pannecouque, Christophe; Lee, Kuo-Hsiung; Chen, Chin-Ho; Zhan, Peng; Liu, Xinyong; European Journal of Medicinal Chemistry; vol. 151; (2018); p. 339 – 350;,
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