Application of 33036-62-3, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 33036-62-3, name is 4-Bromo-1-butanol. A new synthetic method of this compound is introduced below.
After dissolving 4-bromobutanol (5 g, 32.67 mmol) in DMSO (200 mul), the mixture was cooled to 0 C and SO 3 Py (26 g, 163.4 mmol) was added. DIPEA (45 mul, 261.365 mmol) And stirred for 3 hours. The reaction solution was diluted with EtOAc and washed with water. The organic solvent was dried over anhydrous MgSO4, filtered, concentrated by evaporation under reduced pressure, and the resulting residue was purified by silica gel chromatography (n-Hex / EtOAc = 4/1)4-Bromobutane (2.41 g, 49%) was obtained.
At the same time, in my other blogs, there are other synthetic methods of this type of compound,33036-62-3, 4-Bromo-1-butanol, and friends who are interested can also refer to it.
Reference:
Patent; Chungnam National University Foundation of Research & Business; International Medicine Co., Ltd.; Kim Eun-hui; Gu Tae-seong; Jang Gi-hong; Kim Yeong-hun; Lee Ju-hui; Park Chang-min; Oh Se-hwan; Bae Hyeon-ju; Kim Yeong-gwan; (72 pag.)KR2018/56603; (2018); A;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts