Related Products of 722-92-9, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.722-92-9, name is 2-(4-Aminophenyl)-1,1,1,3,3,3-hexafluoropropan-2-ol, molecular formula is C9H7F6NO, molecular weight is 259.15, as common compound, the synthetic route is as follows.
Dichloroglyoxime (0.160 g, 1 mmol) was dissolved in 15 mL of absolute ethanol and was added dropwise to a solution of 2-(4-aminophenyl)-1,1,1,3,3,3-hexafluoro-2-propanol (1.04 g, 4 mmol) in 10 mL of absolute ethanol.The mixture was stirred overnight. Water was added dropwise until a white precipitate formed. It was filtered off, washed with water, and then dried. Compound 2 is soluble in acetone, DMSO, DMF, and THF. Yield:56%; mp 67 C; found: C 39.80, H 2.30, N 9.25; calc. for C20 H14 F12 N4 O4 : C 39.88, H 2.34, N 9.30, IR, numax(cm-1) : 3400 (NH), 3200 (OH), 1610 (C=N), 1519, 1372, 1267 (C-F), 1186 (C-F), 1108, 963 (N-O), 931, 825, 705. 1 H NMR (DMSO-d6) , (ppm): 11.00 (s, 2H, NOH, disappeared upon D2 O), 9.00 (b, 2H, ArCH-OH),8.77-8.51 (d, 4H, Ar-H), 7.66-7.29 (d, 4H, Ar-H), 6.71 (s, 2H, NH); MS (ES), (m/z): 602.3 [M]+.
Statistics shows that 722-92-9 is playing an increasingly important role. we look forward to future research findings about 2-(4-Aminophenyl)-1,1,1,3,3,3-hexafluoropropan-2-ol.
Reference:
Article; Harbeck, Mika; ?en, Zafer; Erbahar, Dilek; Guemue?, Guelay; Musluo?lu, Emel; Turkish Journal of Chemistry; vol. 43; 3; (2019); p. 890 – 901;,
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