Electric Literature of 889884-94-0, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 889884-94-0, name is 7-Fluoronaphthalen-2-ol, molecular formula is C10H7FO, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
General procedure: To a stirred solution of naphthol 35 (100 mg, 0.57 mmol) and azido acetate 13 (300 mg, 1.15 mmol) and 4 A molecular sieves in methylene chloride (40 mL) was added tin(IV) chloride (3.5 mL,1Min DCM, 3.5 mmol) at -78 C. The reaction mixture was stirred at -78 C for 10 min and then the temperature was gradually increasedto -35 C and kept overnight. The reaction was quenched with saturated sodium sulfate and the mixture was extracted with methylene chloride. The organic phase was dried and concentrated and purified by flash column chromatography (using 20% EtOAc/hexanes as eluent) to obtain 39 (43 mg, 20%) as yellow semisolid.
According to the analysis of related databases, 889884-94-0, the application of this compound in the production field has become more and more popular.
Reference:
Article; Mitra, Prithiba; Mandal, Subhajit; Chakraborty, Soumen; Mal, Dipakranjan; Tetrahedron; vol. 71; 34; (2015); p. 5610 – 5619;,
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