Reference of 2215-78-3, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 2215-78-3, name is (4-Phenoxyphenyl)methanol. A new synthetic method of this compound is introduced below.
To a solution of (4-phenoxy-phenyl)-methanol (408 mg, 2.04 mmol) in carbon tetrachloride (8.2 mL) was added triphenylphosphine (642 mg, 2.45 mmol) under nitrogen atmosphere at room temperature, and the reaction solution was stirred under reflux for 7 hours and 40 minutes. The reaction mixture was cooled to room temperature and concentrated under a reduced pressure. The residue was purified by silica gel column chromatography (heptane:ethyl acetate=10:1) to obtain the title compound (409 mg, 92%). 1H-NMR Spectrum (DMSO-d6) delta (ppm): 4.76 (2H, s), 6.98-7.05 (4H, m), 7.15-7.19 (1H, m), 7.39-7.46 (4H, m).
At the same time, in my other blogs, there are other synthetic methods of this type of compound,2215-78-3, (4-Phenoxyphenyl)methanol, and friends who are interested can also refer to it.
Reference:
Patent; Eisai R&D Management Co., Ltd.; US2007/105904; (2007); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts