Adding a certain compound to certain chemical reactions, such as: 2568-33-4, 3-Methylbutane-1,3-diol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, COA of Formula: C5H12O2, blongs to alcohols-buliding-blocks compound. COA of Formula: C5H12O2
To a solution of 3-methylbutane-1 ,3-diol (2.5 ml_) in dichloromethane (30 ml_) and pyridine (2.1 ml_) is added at 0C p-toluene-sulfonylchloride (4.6 g) in portions. The mixture is stirred for 12 hours at room temperature, diluted with dichloromethane and washed with 1 M aqueous HCI solution and brine. After drying (MgSO4) the solvent is evaporated and the product is pu rified by ch romatog raphy on s il ica gel (cyclohexane/ethyl acetate 90:10?70:30) to give the title compound. Yield : 3.2 g; Mass spectrum (ESI+): m/z = 276 [M+NH4]+.
At the same time, in my other blogs, there are other synthetic methods of this type of compound,2568-33-4, 3-Methylbutane-1,3-diol, and friends who are interested can also refer to it.
Reference:
Patent; BOEHRINGER INGELHEIM INTERNATIONAL GMBH; ECKHARDT, Matthias; FRATTINI, Sara; HAMPRECHT, Dieter; HIMMELSBACH, Frank; LANGKOPF, Elke; LINGARD, Iain; PETERS, Stefan; WAGNER, Holger; WO2013/144097; (2013); A1;,
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