Adding a certain compound to certain chemical reactions, such as: 27489-62-9, trans-4-Aminocyclohexanol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Computed Properties of C6H13NO, blongs to alcohols-buliding-blocks compound. Computed Properties of C6H13NO
Preparation of N-Boc-£r°ws-4-aminocyclohexanolcrystallization IValphans-4-aminocyclohexanol hydrochloride (Aldrich, 96.5g, 0.636 mole) was added with mechanical stirring to 636 mL of 1.0N NaOH in a 3L 3N RBF, equipped with a 50OmL addition runnel. After a clear solution was obtained 30OmL of dioxane was added, and then the misture was cooled in an ice bath to about 50C. A solution of di-tert-butyldicarbonate (Aldrich, 138.9g, 0.636 mole) in dioxane (30OmL) was added to the addition runnel and added dropwise to the reaction mixture over 1 hour. The reaction was then allowed to slowly warm to room temperature with stirring in the bath overnight (milky white mixture). The whole was extracted with EtOAc (I x 80OmL, 2 x 50OmL), the organics were combined and washed with water and brine. At this point the product began to precipitate from the organic layer. 400 mL of ethanol was added to aid solubility of the product. The mixture was dried over magnesium sulfate then filtered and evaporated to 50OmL. Then hexanes (600 mL) was added slowly with stirring. The product, N-Boc-^ralphaMs-4-aminocycIohexanoI, was filtered, and washed thoroughly with hexanes to afford the product as white flakes. (98g, 72%).
At the same time, in my other blogs, there are other synthetic methods of this type of compound,27489-62-9, trans-4-Aminocyclohexanol, and friends who are interested can also refer to it.
Reference:
Patent; GLAXO GROUP LIMITED; WO2007/62334; (2007); A2;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts