Adding a certain compound to certain chemical reactions, such as: 130198-05-9, 1-[2-Amino-1-(4-methoxyphenyl)ethyl]cyclohexanol Hydrochloride, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 130198-05-9, blongs to alcohols-buliding-blocks compound. SDS of cas: 130198-05-9
Example 5 Preparation of Tridesmethyl Venlafaxine DDMVxHCl (1 g, 4 mmol), K2CO3 (0.6 g, 4.4 mmol), thiophenol (0.8 ml, 6 mmol) and NMP (4 ml) were charged in a 50 ml flask and heated in a sand bath. The temperature of the bath was kept at 210 C. for 6 hours. HPLC analysis confirmed full consumption of DDMV. TDMV was obtained with a purity of 83.5% by HPLC area percent. Example 6; Preparation of Tridesmethyl Venlafaxine; DDMVxHCl (10 g, 40 mmol), K2CO3 (6 g, 44 mmol), Thiophenol (8 ml, 60 mmol) and NMP (40 ml) were charged in a 250 ml flask equipped with magnetic stirrer, condenser and nitrogen inlet, and heated in a sand bath. The temperature of the bath was kept at 210 C. for 5.5 hours. HPLC analysis confirmed full consumption of DDMV. TDMV was obtained with a purity of 95% by HPLC area percent.; Example 9; Preparation of TDMV from DDMV; DDMV.HCl (10 g, 35 mmol), K2CO3 (5.1 g, 38.4 mmol), Thiophenol (6.2 ml, 52.5 mmol) and NMP (20 ml) were charged in a 100 ml flask equipped with mechanical stirrer, condenser and nitrogen inlet, and were heated in a sand bath. The temperature of the reaction mixture was about 125 C.+/-10 C. for 4 hours. The reaction mixture was cooled to 90 C. and H2O (50 ml) was added dropwise inducing precipitation. The slurry was cooled to 25 C. and stirred for about 80 minutes. The solid was filtered, washed with H2O (20 ml) and left on filter over night and dried at 40 C. under vacuum until constant weight to give white crystalline product (98.5% area purity by HPLC). The compound so-obtained was slurried in water (50 ml) at ambient temperature for 2 hours. The solid was filtered, washed with H2O (20 ml) and left on filter overnight and dried at 40 C. under vacuum to give crystalline product.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,130198-05-9, its application will become more common.
Reference:
Patent; Niddam-Hildesheim, Valerie; Shenkar, Natalia; Shachan-Tov, Sharona; US2008/139849; (2008); A1;,
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