Adding a certain compound to certain chemical reactions, such as: 60666-70-8, (2-Bromo-5-chlorophenyl)methanol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, category: alcohols-buliding-blocks, blongs to alcohols-buliding-blocks compound. category: alcohols-buliding-blocks
Example 74 Synthesis of 2-bromo-5-chloro-3-t-butyldimethylsilyloxy-methylbenzene To the solution of 2-bromo-5-chlorobenzylalcohol (10 g) from Example 73 and imidazole (3.23 g) in dry DMF (50ml) was added dropwise t-butyl chloro dimethylsilane in dry DMF (10 ml) for 20 minutes at -0° C. After addition, the mixture was stirred for 30 minutes at room temperature. The mixture was diluted with ether, and washed with saturated sodium chloride solution, dried over anhydrous sodium sulfate. After removal of the solvent under reduced pressure, the residue was purified by chromatography on a silica gel column (hexane:methylene chloride=4:1) to give the title compound (13.3 g; 88percent).
The synthetic route of 60666-70-8 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Mochida Pharmaceutical Co., Ltd.; US5587392; (1996); A;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts