2516-33-8, Adding some certain compound to certain chemical reactions, such as: 2516-33-8, name is Cyclopropylmethanol,molecular formula is C4H8O, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 2516-33-8.
To a mixture of 2-cyclopropyl-methanol (6.15 g) and DMF (12 mL) was added NaH (60% in mineral oil, 1 .5 g) at 0C. After stirring for 4 hours at RT the mixture was diluted with DMF (5 mL) and 5-bromo-2-fluoro-pyridine (6.00 g) was slowly added keeping the reaction temperature below 300C. After 30 minutes at RT the mixture was heated to 130C for 1 hour by microwave irradiation. After cooling to RT the mixture was diluted with EA and washed with water (3 x). The organic phase was dried (Na2SO4) andconcentrated. The residue was purified by SGC to provide the subtitle compound. MS ESI: mlz = 228 [M+H].
Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 2516-33-8.
Reference:
Patent; SANOFI; SCHWINK, Lothar; BUNING, Christian; GLOMBIK, Heiner; GOSSEL, Matthias; KADEREIT, Dieter; HALLAND, Nis; LOHMANN, Matthias; POeVERLEIN, Christoph; RITTER, Kurt; WO2015/150564; (2015); A1;,
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