Related Products of 2240-88-2, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.2240-88-2, name is 3,3,3-Trifluoropropan-1-ol, molecular formula is C3H5F3O, molecular weight is 114.07, as common compound, the synthetic route is as follows.
A mixture of Description 3 (100 mg, 0.325 mmol), 3,3,3-trifluoropropanol (74 mg, 0.649 mmol) and K2CO3 (134 mg, 0.974 mmol) in MeCN (3 mL) was stirred at 50 0C for 16 h. Additional 3,3,3- trifluoropropanol (30 mg) was added, the temperature raised to 60 0C and the reaction stirred for another 24 h. The reaction was condensed and partitioned between water and dichloromethane. The organic layer was dried over MgSO4 and evaporated. The crude product was purified firstly by preparative thin layer chromatography, eluting with 10 percent methanol in dichloromethane and then by flash column chromatography, eluting with ethyl acetate/dichloromethane [1:1] then ethyl acetate/dichloromethane/ methanol [50:47.5:2.5] to give the title compound (43 mg, 34 percent). 1H NMR (400 MHz, CDCl3) delta 7.67 (1 H, s), 7.45 (2 H, d, J8.6), 7.14 (2 H, d, J 8.7), 4.59 (2 H, t, J6.2), 4.16 (2 H, q, /7.3), 2.53-2.45 (2 H, m), 1.53 (3 H, m). M/z (ES+) 387, 389 (MH-H+).
The chemical industry reduces the impact on the environment during synthesis 2240-88-2, I believe this compound will play a more active role in future production and life.
Reference:
Patent; MERCK SHARP & DOHME LIMITED; WO2006/120481; (2006); A2;,
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