As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 5333-42-6, name is 2-octyldodecan-1-ol, molecular formula is C20H42O, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. Computed Properties of C20H42O
A 500-mL three-necked flask equipped with magnetic stirrer, septum, and thermometer was filled with argon. Triphenylphosphine (33.4 g, 0.127 mol, 1 equiv.) and 200 mL of anhydrous dichloromethane were placed into the flask. The solution was cooled to 0C, and 6.52 mL (20.34 g, 0.127 mol, 1 equiv.) of bromine was added dropwise so that the temperature of the reaction mix- ture was not higher 5C. After bromine addition was completed, the reaction mixture was stirred for 15 min at 0C, 45.36 mL (38.0 g, 0.127 mol, 1 equiv.) of2-octyl-1-dodecanol was added. The reaction mixture was stirred for 12 h at ambient temperature, concen- trated in a vacuum, the resultant suspension was diluted with 100 mL of petroleum ether, and filtered. The filtrate was passed through a thin layer of silica gel, washed with petroleum ether, and concentrated in a vacuum to give 43.61 g (95%) of viscous oil.1H NMR (400 MHz, CDCl3, delta, ppm): 3.47 (d, J =4.7 Hz, 2H), 1.66-1.54 (m, 1H), 1.45-1.17 (m, 32H),0.91 (t, J = 6.7 Hz, 6H).13C NMR (101 MHz, CDCl3, delta, ppm): 39.7, 39.5,32.5, 31.9, 29.8, 29.6, 29.6, 29.5, 29.3, 29.3, 26.5,22.6, 14.1.
With the rapid development of chemical substances, we look forward to future research findings about 5333-42-6.
Reference:
Article; Keshtov; Osipov; Topchiy; Zotova; Konstantinov; Krayushkin; Kuklin; Khokhlov; Doklady Chemistry; vol. 463; 2; (2015); p. 215 – 220; Dokl. Akad. Nauk; vol. 463; 6; (2015); p. 669 – 674,6;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts