Synthetic Route of 15258-73-8, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 15258-73-8, name is (2,6-Dichlorophenyl)methanol, molecular formula is C7H6Cl2O, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
To solution of 6-chloro-1,2,3,4-tetrahydro-2,7-naphthyridine hydrochloride (500 mg;2.44 mmol; 1 eq) in 30 mL toluene were added (2,6-dichlorophenyl)methanol (518 mg; 2.93 mmol; 1.2 eq), 1,4,7,1O,13,16-hexaoxacyclooctadecane (18-Crown-6; 64.4 mg; 0.244 mmol; 1.1 eq) and KOH (547 mg; 9.75 mmol; 4 eq). The mixture was stirred for 3h at RT. The mixture was evaporated and the residue was purified byflash chromatography (silica gel, DCM:MeOH 9:1) giving the product with a yield of 710 mg (1.378 mmol; 47%).
While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 15258-73-8, (2,6-Dichlorophenyl)methanol.
Reference:
Patent; ABBVIE INC.; ABBVIE DEUTSCHLAND GMBH & CO. KG; LANGE, Udo; OCHSE, Michael; VAN DER KAM, Elizabeth; VAN BERGEIJK, Jeroen; TURNER, Sean; OELLIEN, Frank; WALLESER, Patrick; AMBERG, Wilhelm; HORNBERGER, Wilfried; GENESTE, Herve; MEZLER, Mario; HUTCHINS, Charles; (301 pag.)WO2017/36978; (2017); A1;,
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