Related Products of 2240-88-2, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 2240-88-2, name is 3,3,3-Trifluoropropan-1-ol, molecular formula is C3H5F3O, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
methyl 6-hydroxypyrazolo[1,5-a]pyridine-3-carboxylate (0,100 g, 0.520 mmol), 3,3,3-trifluoropiOpan-l -ol (0.096 mL, 1.0 mmol), and l, -(azodicarbonyl)dipiperidine (0.394 g, 1.56 mmol) were placed in a pressure vial. Anhydrous toluene (5 mL) and tri-N-butylphosphine (0,390 mL, 1,56 mmol) were added, and the reaction mixture was stirred at 140 °C under microwave irradiation for 15 min. The reaction mixture was quenched by the addition of MeOH (1 mL), diluted with EtOAc (50 mL), Celite was added, and solvent was removed under reduced pressure. The residue was purified by ISCO (solid loading on Celite, 0-60percent EtOAc/DCM gradient) to give Intermediate 8 (0,064 g, 42 percent yield) as a white solid. MS (ESI) m/z; 289.0 (M+H)+. ‘H-NMR: (500 MHz, DMSO-d6) delta ppm 8.70 (d, 7=1.9 Hz, IH), 8.38 (s, IH), 7.98 (d, J=9.6 Hz, IH), 7.40 (dd, J=9.6, 2.2 Hz, 1H), 4.33 (t, J-5.9 Hz, 2H), 3.82 (s, 3H), 2.85 (qt, J=11.3, 5.8 Hz, 2H). 19F-NMR: (471 MHz, DMSO-d6) delta ppm -63.03 (s, 3F).
According to the analysis of related databases, 2240-88-2, the application of this compound in the production field has become more and more popular.
Reference:
Patent; BRISTOL-MYERS SQUIBB COMPANY; GLUNZ, Peter W.; LADZIATA, Vladimir; DE LUCCA, Indawati; TORA, George O.; MAISHAL, Tarun Kumar; TANGIRALA, Raghuram; THIYAGARAJAN, Kamalraj; (216 pag.)WO2019/14308; (2019); A1;,
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