Adding a certain compound to certain chemical reactions, such as: 623-04-1, (4-Aminophenyl)methanol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 623-04-1, blongs to alcohols-buliding-blocks compound. Safety of (4-Aminophenyl)methanol
Dissolve p-aminobenzyl alcohol (1.20 g, 9.7 mmol) in distilled water (3 mL).Concentrated hydrochloric acid (36% HCl, 3 mL) was added,An aqueous solution (10 mL) of sodium nitrite (NaNO2, 0.69 g, 10.0 mmol) was slowly added dropwise at 0C.After 30 min, a solution of sodium azide (NaN3, 0.78 g, 12.0 mmol) in water (10 mL) was slowly added dropwise.Then stir at room temperature for 14-16 hours, extract three times with ethyl acetate, dry, and spin down to remove ethyl acetate.The obtained p-azidobenzyl alcohol (1.32 g, yield 88.5%) was used directly for the next reaction.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,623-04-1, its application will become more common.
Reference:
Patent; Nankai University; Li Changhua; Chen Haoliang; (17 pag.)CN107417714; (2017); A;,
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