Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 124-68-5, name is 2-Amino-2-methyl-1-propanol. This compound has unique chemical properties. The synthetic route is as follows. Safety of 2-Amino-2-methyl-1-propanol
N-2-Hydroxy-1,1-dimethylethyl carbamic acid tert-butyl ester 2-Amino-2-methylpropan-1-ol (10.0 g, 112 mmol) was dissolved in tetrahydrofuran (100 ml).. A 1N solution of sodium hydroxide in water (112 ml, 112 mmol) was added.. A solution of di-tert-butyl dicarbonate (29.3 g, 134 mmol) in tetrahydrofuran (100 ml) was added over a period of 15 min.. The solution was stirred at 20 C. for 16 h.. water (100 ml) was added.. The phases were separated.. The aqueous phase was extracted with ethyl acetate (3*150 ml) and the combined organic phases were dried (magnesium sulfate).. The solvent was removed in vacuo and the crude product was chromatographed on silica gel (180 g) with ethyl acetate/heptane 1:1 as eluent to give 19.6 g of N-2-hydroxy-1,1-dimethylethyl carbamic acid tert-butyl ester. mp 53 C. 1H-NMR (CDCl3): delta1.22 (s, 6 H); 1.45 (s, 9 H); 3.58 (d, 2 H),; 4.05 (br, 1 H); 4.65 (br, 1 H).
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Reference:
Patent; Novo Nordisk A/S; US6350767; (2002); B1;,
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