Synthetic Route of 534-03-2 ,Some common heterocyclic compound, 534-03-2, molecular formula is C3H9NO2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.
(1) N-(4-Phenoxybenzenesulfonyl)serinol After triethylamine (10.12 g, 100 mmol) was added dropwise to a solution of serinol (3.64 g, 40 mmol) in a mixture of dioxane (100 ml) and water (200 ml), the mixture was stirred at room temperature for 30 minutes. To the reaction mixture, a solution of 4-phenoxybenzenesulfonyl chloride (10.75 g, 40 mmol) in dioxane (100 ml) was added dropwise and this was stirred for 3 hours. Most of the solvent was evaporated under reduced pressure and the residue was extracted with ethyl acetate. The organic layer was washed with water, dried over anhydrous magnesium sulfate and concentrated under reduced pressure to afford the desired compound (10.62 g, yield 82%) as a white powder. 1H-Nuclear magnetic resonance spectrum (400 MHz, CDCl3-DMSO-d6) delta ppm: 7.84 (2H, d, J=8Hz), 7.41 (2H, t, J=8Hz), 7.22 (2H, t, J=7Hz), 7.09-7.01 (4H, m), 6.69 (1H, d, J=7Hz), 4.10-4.06 (1H, m), 3.63-3.45 (4H, m).
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 534-03-2, 2-Aminopropane-1,3-diol, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; Sankyo Company Limited; EP1069110; (2001); A1;,
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