In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 575-03-1 as follows., 575-03-1
General procedure: The corresponding coumarin derivatives (4.21mmol) 5a-k and potassium carbonate (0.872 g, 6.31 mmol) were suspended in dry acetone, and then the corresponding dibromoalkyl derivative (84.12 mmol) was added. The mixture was refluxed for 6 h. After cooling to room temperature, the solid was filtered and washed with acetone. The filtrate was concentrated under reduced pressure and purified by column chromatography using petroleum ether/ethy actate (5 : 1 to 8:1) as eluent to get the intermediates of 6a-n
The chemical industry reduces the impact on the environment during synthesis 575-03-1, I believe this compound will play a more active role in future production and life.
Reference:
Article; He, Qi; Liu, Jing; Lan, Jin-Shuai; Ding, Jiaoli; Sun, Yongbing; Fang, Yuanying; Jiang, Neng; Yang, Zunhua; Sun, Liyuan; Jin, Yi; Xie, Sai-Sai; Bioorganic Chemistry; vol. 81; (2018); p. 512 – 528;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts