Related Products of 534-03-2, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.534-03-2, name is 2-Aminopropane-1,3-diol, molecular formula is C3H9NO2, molecular weight is 91.1091, as common compound, the synthetic route is as follows.
Fmoc-beta-alanine (84.5 g, 271 mmol) and N-hydroxysuccinimide (31.2 g, 271 mmol) are dissolved in dichloromethane (850 mL) and DMF (43 mL) with magnetic stirring. N,N-dicyclohexylcarbodiimide (56.0 g, 271 mmol) dissolved in dichloromethane (100 mL) is added in one portion. After stirring 1.5 hours at room temperature, the reaction mixture was filtered, and transferred to a mixture of serinol (24.7 g, 271 mmol) in pyridine (380 mL) and allowed to react 16 hours overnight. The mixture is evaporated to a semi-solid residue, and co-evaporated 3*400 mL toluene to remove the remaining pyridine. The solid residue is refluxed in dichloromethane (3.0 L) and stored at -20 C. for 2 hours. The product was collect by filtration in a sintered glass funnel, and washed 2*1000 mL dichloromethane, and 1*1000 mL diethyl ether. Drying overnight under high vacuum yielded 92.8 g (89%) of 1.
The chemical industry reduces the impact on the environment during synthesis 534-03-2, I believe this compound will play a more active role in future production and life.
Reference:
Patent; Nelson Biotechnologies, Inc.; Glen Research Corporation; US2011/77389; (2011); A1;,
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