Adding a certain compound to certain chemical reactions, such as: 6338-55-2, 2-(2-(2-Aminoethoxy)ethoxy)ethanol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 6338-55-2, blongs to alcohols-buliding-blocks compound. 6338-55-2
To a 250-mL round-bottom flask was added 2-[2-(2- aminoethoxy )ethoxy ] ethan- 1 -ol (5.3 g, 35.53 mmol, 2 equiv), CH2CI2 (50 mL), triemylamine (5.37 g, 53.07 mmol, 3 equiv), and INT-L3 (R1 = H, 5 g, 17.7 mmol, 1 equiv). The resulting solution was stirred overnight. The reaction was then quenched by the addition of 50 mL of water and extracted with 3 x 50 mL of ethyl acetate. The organic layers were combined, dried over anhydrous sodium sulfate, filtered, and concentrated under vacuum The residue was applied onto a silica gel column with CftCh/methanol (0-55%) providing 6.4 g (92%) of 2-[2-(2-[[4-(benzyloxy)benzene]sulfonamido]ethoxy)emoxy]ethan-l-ol (I T-T1) as a white solid.
With the rapid development of chemical substances, we look forward to future research findings about 6338-55-2.
Reference:
Patent; ARDELYX, INC.; DRAGOLI, Dean; DOTSENKO, Irina; LEWIS, Jason; (439 pag.)WO2018/129552; (2018); A1;,
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