Electric Literature of 6282-88-8 ,Some common heterocyclic compound, 6282-88-8, molecular formula is C9H11ClO, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.
A solution of 3- (4-chlorophenyl) propanol (17.1 g, 0.1 mol) was addedTo DMF (170 ml)Slowly added at 0 C60% NaH (3 g, 0.1 mol),Stir for 30 minutes,Then joinN- (3-bromopropyl) piperidine (22.6 g, 0.11 mol) inDMF (30 mL).The mixture was stirred at 0 & lt; 0 & gt; C2 hours,And then reacted at 20 C for 8 hours.Then diluted with 400 ml of water,Extracted twice with 400 ml of ethyl acetate,Combine organic phase,Washed twice with 2N sodium hydroxide and brine,Dried over magnesium sulfate,filter,Room temperature into the HCl gas,Stir the solid,filter,dry,To obtain 30.7 g of a pale yellow solid product,Yield 92.5%.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,6282-88-8, its application will become more common.
Reference:
Patent; Reyoung Pharmaceutical Co.,Ltd; Hu, qingwen; Cai, lianhui; Cao, Yan; Yu, zhibo; (7 pag.)CN104447620; (2016); B;,
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