Synthetic Route of 722-92-9, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 722-92-9, name is 2-(4-Aminophenyl)-1,1,1,3,3,3-hexafluoropropan-2-ol. A new synthetic method of this compound is introduced below.
General procedure: 28: 2-(4-(ethysulfonyl)phenyl)-A/-(2-fluoro-4-(1, 1,1,3, 3,3-hexafluoro-2-hydroxypropan-2- yl)phenyl)acetamide. To a solution of 2-(4-amino-3-fluorophenyl)-1 ,1 ,1 ,3,3,3-hexafluoropropan-2-ol, (111-12, 50 mg), 2-(4-(ethanesulfonyl)phenyl)acetic acid, IotaIota^ (41.7 mg) and DMAP (4.9 mg) in CH2CI2 (2 ml) was added drop wise at 0°C a solution of DCC (45,4 mg) in CH2CI2 (2 ml). After stirring for 17 hours at room temperature, the reaction mixture was filtered and the solvent was removed under reduced pressure. The residue was purified on S1O2 , using 20percent ethyl acetate in heptane as the eluent, to give the title compound 2^ (4-(ethvlsulfonyl)phenvl)-A/-(2-fluoro-4-(1 , , ,3,3.3-hexafluoro-2-hvdroxvpropan-2-yl) phenvDacetamide (62 mg) as a white solid. MS(ES+) m/z 488 [M+H]+. 1H NMR(500 MHz, DMSO-d6) : delta 10.30 (s, 1 H), 8.91 (s, 1 H), 8.1 1 (dd, 1 H), 7.86 (d, 2H), 7.62 (d, 2H), 7.46-7.52 (m, 2H), 3.94 (s, 2H), 3.28 (q, 2H), 1.1 1 (t, 3H).
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,722-92-9, its application will become more common.
Reference:
Patent; LEAD PHARMA CEL MODELS IP B.V.; CALS, Joseph Maria Gerardus Barbara; NABUURS, Sander Bernardus; WO2015/82533; (2015); A1;,
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