Reference of 86770-74-3, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 86770-74-3, name is 2-(2-(2-(2-Aminoethoxy)ethoxy)ethoxy)ethanol. A new synthetic method of this compound is introduced below.
Step A: (9H-fluoren-9-yl)methyl (2-(2-(2-(2-hydroxyethoxy)ethoxy)ethoxy)ethyl)carbamate (11- 1) To a stirred solution of 2-(2-(2-(2-aminoethoxy)ethoxy)ethoxy)ethanol (1.00 g, 5.17 mmol) in DCM (15 mL) was added 9-fluorenylmethyl chloroformate (1.34 g, 5.17 mmol) and triethylamine ( 1.08 mL, 7.76 mmol). The resulting solution was stirred at room temperature for 10 minutes. The reaction was concentrated onto silica gel and flash column separation using a 0-10% isopropanol/ dichloromethane gradient gave 11-1 as an oil (1.43 g, 66%) LRMS (ES) (M+H)+ : observed = 416.1, calculated = 415.4.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,86770-74-3, its application will become more common.
Reference:
Patent; MERCK SHARP & DOHME CORP; AMBRX, INC; GARBACCIO, Robert, M.; KERN, Jeffrey; BRANDISH, Philip, E.; SHAH, Sanjiv; LIANG, Linda; SUN, Ying; WANG, Jianing; KNUDSEN, Nick; BECK, Andrew; MANIBUSAN, Anthony; GATELY, Dennis; WO2015/153401; (2015); A1;,
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