Electric Literature of 111-45-5, Adding some certain compound to certain chemical reactions, such as: 111-45-5, name is 2-(Allyloxy)ethanol,molecular formula is C5H10O2, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 111-45-5.
A solution of 2-allyloxiethanol (112 g; 1.1 mol) in THF (100 ml) was dripped in a suspension of sodium hydride (60% in oil) (88 g; 2.2 mol) in THF (250 ml) under mechanic stirrer. After 20 h at room temperature, a solution of bromoacetic acid (138.9 g; 1.0 mol) in THF (150 ml) was added dropwise, causing the spontaneous reflux of the solvent. The solution was kept under reflux for 2 hours, then diluted with ethanol (50 ml) and, after 30 min, the suspension was concentrated. The residue was solved on water (400 ml) and the solution was washed with ethyl ether (3*100 ml), dichloromethane (2*100 ml); the aqueous phase was acidified to pH 1 with hydrochloride acid 37% and the product was extracted with dichloromethane (300 ml+4 50 ml). The organic phase was washed with water (4*50 ml), brine (40 ml) and evaporated to a liquid residue that was distilled under vacuum, at a pressure of 67 Pa, to obtained 3,6-dioxa-8-nonenoic acid (I) as colourless liquid (119.5 g; 0.746 mol). Yield 75%. p.eb67-pa 98-100 C. Title 93.5%.
According to the analysis of related databases, 111-45-5, the application of this compound in the production field has become more and more popular.
Reference:
Patent; BRACCO IMAGING S.P.A.; AIME, Silvio; DELLI CASTELLI, Daniela; FEDELI, Franco; LONGO, Dario Livio; TERRENO, Enzo; UGGERI, Fulvio; (37 pag.)US2019/209713; (2019); A1;,
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