Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 124-68-5, name is 2-Amino-2-methyl-1-propanol. This compound has unique chemical properties. The synthetic route is as follows. 124-68-5
N-methyl-2-amino-2-methyl-propan-1 -ol (4)2-Amino-2-methylpropanol (3) (10 g, 0.11 mol), Na2CO3 (0.41 g), NaHCO3 (0.41 g) and 3:1 dioxane/water (41 ml) were stirred together at 00C. Boc anhydride (29.4 g, 0.13 mol) was added slowly and the reaction was stirred at room temperature for 6 h. The salts formed were filtered and washed with DCM. The filtrate was diluted with water (50ml) and extracted with DCM (3 x 50 ml), dried (Na2SO4) and evaporated to dryness, giving a white solid. This was dissolved in THF (100 ml) and added dropwise to a mixture of lithium aluminium hydride (12.7 g, 0.33 mol) in THF (200 ml). The mixture was heated to reflux overnight then cooled to room temperature. Water (15 ml) was added slowly with ice-cooling followed by 4 M NaOH (15 ml), and then more water (45 ml). The white solids were filtered, washed with THF, and the filtrate was evaporated to dryness, giving a pink solid (8.9 g, 77%). 1H NMR (400 MHz, CDCI3): 0.97 (6H, s), 2.24 (3H, s), 3.26 (2H, s); 13C NMR (100 MHz, CDCI3): 23.27, 28.41 , 53.62, 68.26.
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Reference:
Patent; BIOCOPEA LIMITED; BANNISTER, Robin Mark; WO2010/103312; (2010); A1;,
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