Related Products of 456-47-3, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 456-47-3, name is 3-Fluorobenzyl alcohol. A new synthetic method of this compound is introduced below.
General procedure: Sodium hydride (60% in mineral oil, 0.04g, 1mmol) was added to a stirred solution of benzyl alcohol derivative (1mmol) in anhydrous N,N-dimethylformamide (3mL of DMF) at room temperature and stirring was continued for 1h. 2-Amino-3-chloropyrazine (10b, 0.13g, 1mmol) was added to the reaction mixture and the reaction mixture was stirred at 100C for 15h. After cooling, the solvent was evaporated and the residue was partitioned between water and dichloromethane. The organic layer was dried over sodium sulfate anhydrous, filtered, and concentrated. The residue was purified by column chromatography (SiO2, EA/n-Hex=1/5). 4.1.2.1 3-(3-Fluorobenzyloxy)pyrazin-2-amine (11e) (0027) Light orange solid, yield: 75.6%, 1H NMR (400MHz, DMSO-d6) delta=5.39 (2H, s, OCH2Ph), 6.36 (2H, br, NH2), 7.14 (1H, td, J=2.6Hz, 9.0Hz, ArH), 7.25 (1H, d, J=3.1Hz, ArH), 7.32 (1H, d, J=7.6Hz, ArH), 7.37-7.44 (2H, m, ArH), 7.49 (1H, d, J=3.1Hz, ArH).
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,456-47-3, its application will become more common.
Reference:
Article; Park, Jung-eun; Elkamhawy, Ahmed; Hassan, Ahmed H.E.; Pae, Ae Nim; Lee, Jiyoun; Paik, Sora; Park, Beoung-Geon; Roh, Eun Joo; European Journal of Medicinal Chemistry; vol. 141; (2017); p. 322 – 334;,
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