Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 28539-02-8, name is 1-(Hydroxymethyl)benzotriazole. A new synthetic method of this compound is introduced below., Quality Control of 1-(Hydroxymethyl)benzotriazole
To a stirred solution of n-BuLi (2.5 M in hexanes, 22.9 ml, 57.4 mmol) in THF(120 ml) was added dropwise iPr2NH (8.11 ml, 57.4 mmol) at -10 C. The solution was allowed to stir at 0 C for 30 min and then cooled to -78 C. Enone 83 (8.62 g, 19.1 mmol) inTHF (25 ml) was added and stirring was continued for 1 h. 1H-Benzotriazole-1-methanol in THF (175 ml) was added dropwise and the reaction mixture was kept 2 h at -78 C. The reaction was quenched with water (85 ml) and extracted with Et2O (2 × 250 ml). The combined organic layers were washed successively with 4 M NaOH (85 ml) and brine (85 ml), dried (MgSO4) and concentrated in vacuo. Purification by flash chromatography onsilica gel with petroleum ether/EtOAc 9:1 to 6:1 as eluent gave alcohol S28 (6.10 g, 67%) as a colourless oil.
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Reference:
Article; Bruss, Hanna; Schuster, Hannah; Martinez, Remi; Kaiser, Markus; Antonchick, Andrey P.; Waldmann, Herbert; Beilstein Journal of Organic Chemistry; vol. 10; (2014); p. 194 – 208;,
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