With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.431-38-9, name is 3-Amino-1,1,1-trifluoropropan-2-ol, molecular formula is C3H6F3NO, molecular weight is 129.0811, as common compound, the synthetic route is as follows.Recommanded Product: 3-Amino-1,1,1-trifluoropropan-2-ol
General procedure: Sodium triacetoxyhydroborate (900 mg, 4.2 mmol) was added to a solution of 1-naphthaldehyde (2.8 mmol) and the amine (2.8 mmol) in 1,2-dichloroethane (80 mL) at r.t. under nitrogen atmosphere. The reaction mixture was stirred for 6 h at r.t. and was quenched with sat. aq. NaHCO3 (20 mL) and extracted with DCM (3 x 50 mL). The combined organic layer was washed with brine (50 mL), dried and evaporated. The compound was purified by preparative HPLC on a XBridge C18 column (10 m 250×19 ID mm) using a gradient of 30-80% Acetonitrile in H2O/ACN/NH3 95/5/0.2 buffer over 20 minutes with a flow of 19 mL/min. The compounds were detected by UV at 220 nm to provide the product.
At the same time, in my other blogs, there are other synthetic methods of this type of compound,431-38-9, 3-Amino-1,1,1-trifluoropropan-2-ol, and friends who are interested can also refer to it.
Reference:
Article; Giordanetto, Fabrizio; Wallberg, Andreas; Ghosal, Saswati; Iliefski, Tommy; Cassel, Johan; Yuan, Zhong-Qing; Von Wachenfeldt, Henrik; Andersen, Soren M.; Inghardt, Tord; Tunek, Anders; Nylander, Sven; Bioorganic and medicinal chemistry letters; vol. 22; 21; (2012); p. 6671 – 6676,6;,
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