New downstream synthetic route of 109-83-1

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 109-83-1, 2-(Methylamino)ethanol.

Reference of 109-83-1, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 109-83-1, name is 2-(Methylamino)ethanol. This compound has unique chemical properties. The synthetic route is as follows.

To a solution of carbon disulfide (452 pL, 7.5 mmol, 1.5 eq.) in 10 mL anhydrous THF under intert atomsphere of argon, is added dropwise at 0 C 2-(methylamino)ethanol (400pL, 5.0 mmol, 1.0 eq.). After stirring atO Cfor5 minutes, sodium hydride (60% dispersion inmineral oil, 200 mg, 5.0 mmol, 1 .0 eq.) is added in portions. After 30 minutes of stirring at 0 0C the mixture is concentrated under reduced pressure and washed with cyclohexane toremove mineral oil and dried overnight under reduced pressure to yield a pale yellow powder (842 mg, 4.9 mmol, 97 % yield).1H NMR (400 MHz, MeOD) 6 (ppm): 3,57 (s, 3H, CH3), 3,87 (t, J = 6 Hz, 2H, CH2N),4,27 (t, J = 6 Hz, 2H, CH2O)130 NMR (100 MHz, MeOD) 6 (ppm): 44,7 (CH3N), 59,1 (CH2N), 61,2 (CH2O), 214,0 (CS2).

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 109-83-1, 2-(Methylamino)ethanol.

Reference:
Patent; UNIVERSITE PARIS EST CRETEIL VAL DE MARNE; CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS); INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM); MOTTERLINI, Roberto; FORESTI, Roberta; MARTENS, Thierry; RIVARD, Michael; WO2015/140337; (2015); A1;,
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