647-42-7, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 647-42-7, name is 3,3,4,4,5,5,6,6,7,7,8,8,8-Tridecafluorooctan-1-ol, molecular formula is C8H5F13O, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
General procedure: To a stirred solution of the corresponding thiazoline 4a-c (2.0 mmol) in dry CH2Cl2 (8 mL) under N2 atmosphere at room temperature, were added subsequently the corresponding alcohol (2.0 mmol) EDCI (2.0 mmol) and catalytic amount of DMAP. After 16 h, the organic phase was transferred to an extraction funnel, washed with saturated NaHCO3 (2 ¡Á 10 mL), water (2 ¡Á 10 mL) and the organic layer was dried with Na2SO4. The solvent was evaporated and the remaining product was purified by chromatography (hexanes/AcOEt = 80:20).
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 647-42-7, 3,3,4,4,5,5,6,6,7,7,8,8,8-Tridecafluorooctan-1-ol, other downstream synthetic routes, hurry up and to see.
Reference:
Article; Schneider, Juliana M. F. M.; Sales, Eric S.; Livotto, Paolo R.; Schneider, Paulo H.; Merlo, Aloir A.; Journal of the Brazilian Chemical Society; vol. 25; 8; (2014); p. 1493 – 1503;,
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