In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 534-03-2, name is 2-Aminopropane-1,3-diol, the common compound, a new synthetic route is introduced below. Quality Control of 2-Aminopropane-1,3-diol
0.91 g of 2-amino-l , 3-propandiol and 1.13 g of triethylamine are solubilised in 15 ml of tetrahydrofuran at 0C. The solution is stirred and placed under nitrogen atmosphere. A solution of 2.74 g of palmitoyl chloride is added dropwise slowly within 30 min. After another 30 min of stirring at ambient temperature, the mixture is dry evaporated. The residue is solubilised using 15 ml of ethyl acetate and extracted using 10 ml of water which is disposed. The organic phase is anhydrified using Na2S04 and dry evaporated under vacuum. The raw amide thus obtained is used without further purification. The residue is suspended at 0C and under nitrogen gas atmosphere in 20 ml of S0C12. The mixture is stirred at 0C for 30 minutes, then at ambient temperature for 6 hours. The solution thus obtained is dry evaporated at a low pressure. The residue is purified by crystallization from 15 ml of tert-butyl methyl ether, isolated and dried under vacuum. The crystallized product is suspended in 20 ml of anhydrous toluene and 1.3 g of potassium tert- butoxide are added. The mixture is heated at 40C for 2 hours, then it is cooled at 4C. The solution is extracted 3 times using 6 ml of water and the extracts are disposed. The organic phase is dry evaporated at’ a low pressure and the residue purified through flash chromatography in a column of silica gel using – as eluent – a mixture of hexane and ethyl acetate 1:3. The fractions containing the pure product are recombined and dry evaporated under vacuum. (About 90% yield) The 2-pentadecyl-4-hydroxymethyl-2-oxazoline product has the following characteristics: Molecular formula C19H37N02; C=73.26%, H=11.97%, N=4.50%, 0=10.27%; Solubility: poorly soluble in water, >10 mg/ml in ethanol; Mr 311.5; ESI-MS: 312 (MH+) .
The synthetic route of 534-03-2 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; EPITECH GROUP S.r.L.; DELLA VALLE, Francesco; DELLA VALLE maria Federica; DI MARZO, Vincenzo; CUZZOCREA, Salvatore; WO2013/121449; (2013); A1;,
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