Related Products of 28539-02-8, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 28539-02-8, name is 1-(Hydroxymethyl)benzotriazole, molecular formula is C7H7N3O, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
3. 3-(4-tert-butylsulfanvIthieno[3,2-d]pyrimidin-7-yl)-5-(hydroxymethyl)cyclopent-2-en-1-one Lithium bis(trimethylsilyl)amide (1.0 M in THF, 0.66 mL, 0.66 mmol) is added to a solution of 3-(4-tert-butylsulfanylthieno[3,2-d]pyrimidin-7-yl)cyclopent-2-en-1-one (0.10 g, 0.33 mmol) in THF (2.0 mL) at -78 C. and the resulting mixture is stirred at this temperature over 1 hr. To this mixture, a solution of 1-hydroxymethylbenzotriazole (0.10 g, 0.66 mmol) in a mixture of THF (1.0 mL) and hexamethylphosphoramide (HMPA, 0.10 mL) is added. The resulting mixture is stirred at -78 C. for 2 hr then quenched with saturated aqueous NH4Cl (1.0 mL). THF is removed in vacuo and the resulting residue is taken up in dichloromethane, dried with Na2SO4, filtered and concentrated in vacuo. The crude is purified by chromatograph to give desired title compound as a solid (0.08 g, 69%). LCMS (m/z) M+H=335.4; tR=2.89 min.
While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 28539-02-8, 1-(Hydroxymethyl)benzotriazole.
Reference:
Patent; Wang, Zhong; Smith, Emilie D.; Veal, James M.; Huang, Kenneth H.; Atkinson, Robert N.; Jiang, Rong; US2012/77814; (2012); A1;,
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