Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 42514-50-1, name is 3-Amino-3-methylbutan-1-ol. A new synthetic method of this compound is introduced below., HPLC of Formula: C5H13NO
To a stirred suspension of sodium hydride (0.3Og, 80% dispersion in mineral oil) in dry N,N-dimethylformamide (2ml) under an atmosphere of nitrogen at ambient temperature was added dropwise a solution of 1-hydroxy-3-methylbut-3-ylamine (0.52g) in N1N- dimethylformamide (5ml). The mixture was stirred for 3 hours, methyl iodide (0.74g) in N,N-dimethylformamide (5ml) added over 5 minutes then stirred for another 2.25 hours and stored for 18 hours at ambient temperature. The solution was diluted with water, extracted into ethyl acetate (three times) and the extracts combined then extracted with dilute hydrochloric acid. The aqueous acidic extract was evaporated under reduced pressure and co-distilled with toluene to remove residual water to give 1-methoxy-3- methylbut-3-ylamine hydrochloride as a yellow gum.1H NMR (CDCI3) delta ppm: 1.54(6H,s); 1.96-2.00(2H,t); 3.48(3H,s); 3.62-3.66(2H,t).
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Reference:
Patent; SYNGENTA PARTICIPATIONS AG; WO2008/110355; (2008); A1;,
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