The origin of a common compound about 7589-27-7

At the same time, in my other blogs, there are other synthetic methods of this type of compound,7589-27-7, 2-(4-Fluorophenyl)ethanol, and friends who are interested can also refer to it.

With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.7589-27-7, name is 2-(4-Fluorophenyl)ethanol, molecular formula is C8H9FO, molecular weight is 140.16, as common compound, the synthetic route is as follows.HPLC of Formula: C8H9FO

2-(4-Fluorophenyl)~ethanol (7.13 mmol) was dissolved in dichloromethane (10 m.pound.), to which methanesulfonyl chloride (7.84 mmol) and triethylamine (10.7 mmol) were added. The mixture was slowly to react at room temperature for 1 hour, the reaction mixture was washed with IN hydrochloric acid, and water was added thereto. The resultant was extracted with dichloromethane and washed with brine. The organic layer was dried over Na2SO4 and concentrated under a reduced pressure, to obtain the title compound.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,7589-27-7, 2-(4-Fluorophenyl)ethanol, and friends who are interested can also refer to it.

Reference:
Patent; KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY; HANALL PHARMACEUTICAL COMPANY LTD.; WO2008/16278; (2008); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts