Analyzing the synthesis route of 202865-66-5

Statistics shows that 202865-66-5 is playing an increasingly important role. we look forward to future research findings about (2-Bromo-5-fluorophenyl)methanol.

Application of 202865-66-5, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.202865-66-5, name is (2-Bromo-5-fluorophenyl)methanol, molecular formula is C7H6BrFO, molecular weight is 205.02, as common compound, the synthetic route is as follows.

General procedure: 2-Halobenzyl tosylates 1a-e were prepared from the corresponding 2-halobenzyl alcohols according to the procedure of Wallace et al.38 p-TsCl (3.2 mmol) was added to a stirred solution of the 2-halobenzyl alcohol (2.7 mmol) in Et2O (15 mL) at 0 C. After addition of freshly powdered KOH (27 mmol) in small portions, the reaction mixture was stirred for 3 h at room temperature. The ethereal solvent was removed in vacuo and the reaction mixture was poured into water (50 mL). The precipitate formed was collected by filtration and purified by flash chromatography over silica gel.

Statistics shows that 202865-66-5 is playing an increasingly important role. we look forward to future research findings about (2-Bromo-5-fluorophenyl)methanol.

Reference:
Article; Omar, Mohamed A.; Conrad, Juergen; Beifuss, Uwe; Tetrahedron; vol. 70; 35; (2014); p. 5682 – 5695;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts