Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 111-46-6, name is 2,2′-Oxybis(ethan-1-ol). A new synthetic method of this compound is introduced below., Quality Control of 2,2′-Oxybis(ethan-1-ol)
General procedure: Dioxane (15 mL), alkyl halide (25 mmol), and tetrabutylammonium bromide (0.4 g, 1.2 mmol) were added to a solution of KOH (1.6 g, 27.5 mmol) in glycol (75-125 mmol). After stirring at 100-105 C for 5-10 h, the reaction mixture was diluted with CHCl3 (15 mL) and water (10 mL). The organic layer was separated, washed with water (3×20 mL), dried with Na2SO4, and evaporated in vacuo, and the residue was distilled using Vigreux column. For each particular case, the ratio of the starting reagents, yields, physicochemical parameters, and 1H NMR spectral data for monoalkyl ethers 8a-e are givenin Table 6.
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Reference:
Article; Kharlamov; Artyushin; Bondarenko; Russian Chemical Bulletin; vol. 63; 11; (2014); p. 2445 – 2454; Izv. Akad. Nauk, Ser. Khim.; 11; (2014); p. 2445 – 2454;,
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