Extended knowledge of 68208-26-4

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 68208-26-4, 3-Amino-3-(4-chlorophenyl)-1-propanol.

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 68208-26-4, name is 3-Amino-3-(4-chlorophenyl)-1-propanol. This compound has unique chemical properties. The synthetic route is as follows. Product Details of 68208-26-4

Intermediate 30: tert-butyl l-(4-chlorophenyl)-3-hvdroxypropylcarbamateDi-tert-butyl dicarbonate (0.705 g, 3.23 mmol) was added to 3-amino-3-(4- chlorophenyl)propan-l-ol (Intermediate 29) (0.500 g, 2.69 mmol) in DCM (30 mL) at 220C. The resulting solution was stirred at 22 0C for 2 hours. The mixture was concentrated and the residue was purified by flash silica chromatography, elution gradient 0 to 4% (10:1 MeOH/conc. NH3 (aq)) in DCM. Pure fractions were evaporated to dryness to afford tert-butyl l-(4-chlorophenyl)-3-hydroxypropylcarbamate (0.759 g, 99 %) as a white solid.IH NMR (399.902 MHz, CDC13) delta 1.43 (9H, s), 1.81 (IH, m), 2.04 (IH, m), 2.74 (IH, br.s), 3.69 (2H, m), 4.88 (IH, br.s), 5.04 (IH, d), 7.23 (2H, d), 7.32 (2H, d). MS m/e MH” 284, 286

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 68208-26-4, 3-Amino-3-(4-chlorophenyl)-1-propanol.

Reference:
Patent; ASTRAZENECA AB; ASTRAZENECA UK LIMITED; WO2009/47563; (2009); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts